NCT06083766

Metabolic and Physiologic Responses to Hormone Therapy in Transgender and Gender Diverse People

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 24 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The primary purpose of this research is to determine how gender affirming hormone therapy affects muscle physiology.

Detailed description

Study participation involves a screening visit and two study visits. The screen includes blood draws, and urine testing. The first visit requires a collection of breath, exercise testing, and body scans. Between visits participant are to eat three days of provided meals and wear an activity monitor. The second study visit will be 3-14 days after the first and includes blood draws, a meal test, and a muscle biopsy. If individuals are not on gender affirming hormone therapy at the time of participation, they may be able to participate again if you decide to pursue gender affirming hormone therapy later on.

Conditions

• Effects of GAHT, on Skeletal Muscle in TGD

Interventions

Type	Name	Description
BEHAVIORAL	hormone therapy	Determine how gender affirming hormone therapy affects muscle physiology

Timeline

• Start date: 2024-01-04
• Primary completion: 2026-04-01
• Completion: 2026-07-01
• First posted: 2023-10-16
• Last updated: 2025-11-10

Locations

1 site across 1 country: United States