NCT06082726

The Systemic Concentration of Short-Chain Fatty Acids After Delivery in the Small and Large Intestine of Healthy Volunteers

The Systemic Availability of Short-Chain Fatty Acids After Delivery in the Small Intestine and the Colon

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: KU Leuven · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The goal of this crossover study is to evaluate the systemic availability of short-chain fatty acids (SCFA) that are either administered in the small intestine or the colon in healthy volunteers. The main question it aims to answer is whether the site of administration affects the amount of SCFA that reaches the systemic circulation. On two test days participants will ingest capsules filled with SCFA that are specifically delivered in the small intestine or the colon. After ingestion, blood samples will be collected at regular time points.

Conditions

• Systemic Availability
• Intestinal Absorption
• Metabolism
• Short-chain Fatty Acids

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	SCFA	Participants will ingest the capsules during a standard no fiber breakfast. A primed continuous infusion containing SCFA will run during the whole test day. Blood sampling will continue for 12 hours.

Timeline

• Start date: 2023-10-09
• Primary completion: 2024-03-11
• Completion: 2024-03-11
• First posted: 2023-10-13
• Last updated: 2026-02-23

Locations

1 site across 1 country: Belgium