NCT06079424

Risk Markers of Arterial Aging. The Paris Prospective Study III-2

Risk Markers of Arterial Aging and Subsequent Risk of Cardiovascular Diseases and Beyond. The Paris Prospective Study III-2

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 7,500 (estimated)
• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France · Other Government
• Sex: All
• Age: 60 Years – 95 Years
• Healthy volunteers: Accepted

Summary

The main objectives of PPS3-2 are (i) to describe the dynamics of vascular aging and baroreflex sensitivity 12 to 16 years a part, (ii) to identify their determinants, and (iii) to quantify the subsequent risk of cardiovascular diseases.

Detailed description

Since May 2008, PPS3 is being following the CVD morbidity of 10157 healthy volunteers aged 50-75 years at baseline. In PPS3-2, we plan to re-invite survivors and volunteers of PPS3 to undergo a second physical examination. In particular, they will undergo a second high-precision carotid echotracking to measure vascular aging parameters and baroreflex sensitivity, permitting to study their respective dynamics. They will also underwent for the first time ultra fast echo of the radial artery to measure vascular aging parameters of the medium-sized arteries. According to fundings, blood samples will be taken and stored at -80°C in the whole population or in a subsample.

Conditions

• Arterial Stiffness

Interventions

Type	Name	Description
OTHER	high-precision carotid echo-tracking	evaluation of vascular aging parameters and baroreflex sensitivity

Timeline

• Start date: 2025-06-20
• Primary completion: 2031-05-01
• Completion: 2033-12-01
• First posted: 2023-10-12
• Last updated: 2025-09-11

Locations

1 site across 1 country: France