NCT06077786

A Trial Investigating the Pain-relieving Properties of Lu AG06474 in Healthy Adult Participants

An Interventional Randomized, Double-blind, Placebo and Active Comparator-controlled, Four-way Crossover Trial Investigating the Analgesic Properties of a Single Oral Dose of Lu AG06474 in Healthy Participants

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: H. Lundbeck A/S · Industry
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The main goal of this trial is to learn about the effect of Lu AG06474 on a battery of Evoked Pain Tests when a single dose is given to healthy adult participants. The effects of Lu AG06474 will be compared with 2 approved pain-relieving medications (ibuprofen and pregabalin) and with a placebo (a treatment that looks like the trial treatment but does not have any medicine in it). Each participant will receive 1 dose of each of these treatments during the trial (Lu AG06474, ibuprofen, pregabalin, and placebo), with 1 week between treatments. All treatments will be taken orally (by mouth), either as a liquid or a capsule.

Conditions

• Healthy Participants

Interventions

Type	Name	Description
DRUG	Lu AG06474	Oral solution
DRUG	Placebo to Lu AG06474	Oral solution
DRUG	Ibuprofen	Capsule
DRUG	Pregabalin	Capsule
DRUG	Placebo	Capsule

Timeline

• Start date: 2023-10-13
• Primary completion: 2024-05-10
• Completion: 2024-05-17
• First posted: 2023-10-11
• Last updated: 2024-06-28

Locations

1 site across 1 country: Netherlands