NCT06076629

Acute Health Effects of Low Temperature Exposure

Acute Health Effects of Low Temperature Exposure in Healthy Young Adults: A Randomized Controlled Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Fudan University · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of low temperature exposure and the underlying mechanisms.

Detailed description

The investigators will conduct a randomized controlled human exposure crossover study among about 50 healthy young adults in Shanghai, China. Each subject will be exposed twice: once to the low temperature (16#) and once to the moderate temperature (22#) in a chamber for about 2-2.5 hours. During the exposure session, each subject will be requested to rest. Health examinations will be conducted immediately prior to exposure (within 1 hour before the exposure session), during the period of exposure, and after exposure (within 2 hours after the exposure session). Health examinations include spirometry, Holter monitoring, blood pressure tests, cognitive function tests, symptom questionnaires, and magnetic resonance imaging. Investigators plan to collect blood, urine, exhaled breath condensate, and oropharyngeal swabs samples.

Conditions

• Cardiovascular System
• Respiratory System
• Cognitive Function

Interventions

Type	Name	Description
OTHER	Low temperature (16#) group	The exposure group will be exposed to low temperature (16#) in a chamber for about 2 hours, resting during the whole periods.
OTHER	Moderate temperature (22#) group	The exposure group will be exposed to thermoneutral temperature (22#) in a chamber for about 2 hours, resting during the whole periods.

Timeline

• Start date: 2023-10-10
• Primary completion: 2023-11-15
• Completion: 2024-12-31
• First posted: 2023-10-11
• Last updated: 2023-10-11

Locations

1 site across 1 country: China