NCT06073340

The Longitudinal Study of Stimulant Use Disorder

Observational Longitudinal Study of Individuals With Stimulant Use Disorder: Research and Development of a Biosignature

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 72 (actual)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

This research is a 5-year observational, longitudinal registry study with no treatment or medication provided as part of participation. Individuals with current or lifetime stimulant use disorder, in addition to healthy control individuals, may be eligible to participate in this study. A variety of assessments and tasks including Magnetic Resonance Imaging (MRI), Electroencephalography (EEG), blood draws, urine drug screens, and both self-report and clinician-rated assessments will be used to assess biomarkers in this population. This study has a visit schedule of four in-person visits and eight remote visits per year.

Detailed description

This project is a five-year observational study that will use a variety of assessments and tasks to phenotype participants with lifetime or current Stimulant Use Disorder as well as healthy control individuals. The data collection will include collecting urine samples for diagnostic tracking, socio-demographic and lifestyle factors, clinical and behavioral assessments, blood-based biomarkers, genomics, cell-based assays, EEG, and MRI to establish phenotypic biosignature subtypes over the longitudinal timeline.

Conditions

• Stimulant Use
• Stimulant-Related Disorder
• Healthy

Timeline

• Start date: 2023-11-16
• Primary completion: 2025-03-31
• Completion: 2025-03-31
• First posted: 2023-10-10
• Last updated: 2025-04-08

Locations

1 site across 1 country: United States