NCT06072378

The Computational and Neural Mechanisms Linking Decision-making and Memory in Humans

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Rutgers, The State University of New Jersey · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Learning to make good decisions in the present, and accurately recalling events and information from the past, are critical aspects of human cognition that are often impaired in many psychiatric disorders. This project aims to identify the how the choices individuals make influence what, and how, people remember by combining disparate techniques in computational modeling and direct brain recordings in human subjects. The researcher developed a dual-task paradigm, probing how decisions in one task affect immediate recognition memory. To examine the neural mechanisms underlying model-free RL's influence on memory, the researcher will record local field potential (LFP) and single neuron activity in various brain regions as epilepsy patients perform the proposed task. The results of this project will identify specific neurocomputational mechanisms unifying decision-making and memory processes.

Conditions

• Memory, Short-Term

Interventions

Type	Name	Description
BEHAVIORAL	Value-manipulation	During the decision-making task, different choices are assigned different values probabilistically.

Timeline

• Start date: 2023-10-31
• Primary completion: 2028-09-01
• Completion: 2028-09-01
• First posted: 2023-10-10
• Last updated: 2025-12-17

Locations

1 site across 1 country: United States