NCT06071403

The Effects of Time Points to Cease Parenteral Nutrition and IGF-1 on Very Low Birth Weight Infants

The Effects of Time Points to Cease Parenteral Nutrition and IGF-1 on Very Low Birth Weight Infants--A Multicenter Prospective Cohort Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 416 (estimated)
• Sponsor: Peking University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

This study aims to estimate short-term and long-term effects of time points to cease parenteral nutrition on very preterm infants, such as growth; to estimate the role of insulin-like growth factor 1 in the growth.

Detailed description

At present, it is unclear when to cease parenteral nutrition, the effects of cessation times on preterm infants' growth, and whether insulin-like growth factor 1 (IGF-1) has a mediation effect in the procedure that nutrients regulate the growth in preterm infants. Therefore, a prospective cohort study was designed with the aims: 1. to estimate the association between the time to cease parenteral nutrition and the growth in very low birth weight; 2. to investigate the relationship between nutrient volume in parenteral nutrition and growth in very low birth weight; 3. to analyze the IGF-1 mediation effect between nutrient volume and growth regulations.

Conditions

• Growth Retardation

Interventions

Type	Name	Description
OTHER	(enteral feeding volume/ total fluid volume)*100%	(enteral feeding volume/ total fluid volume)\*100%. Total fluid volume is defined as enteral feeding volume + parenteral fluid volume + other fluid volume

Timeline

• Start date: 2023-07-01
• Primary completion: 2024-06-30
• Completion: 2026-09-30
• First posted: 2023-10-06
• Last updated: 2023-10-06

Locations

1 site across 1 country: China