NCT06069505

Detection of Azole Resistance Inducing Mutations on DNA Extracted Directly From Serum or Plasma of Immunocompromised Patients With an Invasive Aspergillus Infection Azole Resistance PCR Optimalization-study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Bart Rijnders · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

Invasive aspergillosis (IA) is the most common mould infection in immunocompromised patients with haematological disease. Voriconazole, a triazole, improves overall survival of patients with an IA and is the mainstay of therapy. Resistance of A. Fumigatus emerged as an important clinical problem and infections with azole resistant Aspergillus have a high mortality. Nowhere in the world, azole resistance is more prevalent than in the Netherlands. Rapid detection of resistance is key to improve the patient's outcome but fungal cultures take time and are often negative. The investigators aim to detect azole resistance associated mutations in fungal DNA extracted directly from serum or plasma to accelerate diagnosis and improve outcome of patients infected with azole resistant A. fumigatus.

Conditions

• Invasive Aspergillosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Aspergillus PCR	Aspergillus PCR will be performed on different volumes of serum and plasma of patients with hematological malignancies with suspicion for invasive fungal infection.

Timeline

• Start date: 2017-07-01
• Primary completion: 2030-12-31
• Completion: 2030-12-31
• First posted: 2023-10-05
• Last updated: 2024-05-07

Locations

1 site across 1 country: Netherlands