NCT06055894

A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM) or Monoclonal Gammopathy of Undetermined Significance (MGUS)

Microbial Changes in Response to a Plant Based Diet and/or Supplements in SMM/MGUS Patients: A National Multi-Arm Randomized Prospective Telehealth Study Via HealthTree

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Memorial Sloan Kettering Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The researchers are going this to look at how butyrate levels change in participants' stool after they are on a plant-based diet or dietary supplements (omega-3, curcumin or probiotics) for 2 weeks. All participants will have smoldering multiple myeloma (SMM) or monoclonal gammopathy of undetermined significance (MGUS). The researchers will compare how the different dietary changes affect butyrate levels in participants' stool.

Conditions

• Multiple Myeloma, Smoldering
• Multiple Myeloma
• Monoclonal Gammopathy of Undetermined Significance

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Omega-3	For 2 weeks, patients will receive omega 3 fatty acid supplements 1640 mg (2 capsules) twice daily
DIETARY_SUPPLEMENT	Curcumin	For 2 weeks, patients in the curcumin arm will receive Curcumin C3 complex 1000 mg with 5 mg BioPerine twice daily
DIETARY_SUPPLEMENT	Probiotic	For 2 weeks, patients in the probiotic arm will receive Ultra-50 probiotics with 50 billion CFU per capsule (one capsule) twice daily
OTHER	Whole food, plant-based diet (WFPBD)	Daily Harvest once a week. The meals will have range from 2 breakfast, 11 lunch/dinners, 1 snack (provided Week 1), and whole grains items (provided Week 2).

Timeline

• Start date: 2023-09-20
• Primary completion: 2026-09-01
• Completion: 2026-09-01
• First posted: 2023-09-28
• Last updated: 2025-11-13

Locations

7 sites across 1 country: United States