NCT06055764

Role of FDG PET/CT in Patients With Metastasis of Unknown Origin

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 73 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

Evaluatation of the role of F18FDG-PET/CT in patients with metastases of unknown origin.

Detailed description

Cancer of unknown primary origin (CUP) includes a cluster of heterogeneous tumors that have exceptional clinical features: it is defined as early apparent metastatic disease with no recognizable primary site at the time of presentation. The incidence of CUP ranges around 2% of all new cancer diagnoses. The work up list of CUP include; a biopsy proven malignancy, a detailed physical examination, many laboratory, radiological and endoscopy. However, these investigations may be costly time-consuming and may eventually fail to detect the site of the primary malignant tumor in the majority of patients. In this context, positron-emission tomography (PET) combined with computed tomography (PET/CT), using the radiotracer 18F fluoro- 2-deoxyglucose (FDG) is an alternative, non-invasive imaging modality with accurate diagnostic performance. It considered good tool for diagnosis of patients with CUP . The basis for use of FDG as radiotracer for PET imaging in CUP depends on the fact that most of the malignant cancer phenotypes show an increased glucose metabolism rate. Failure to identify the primary tumor hampers optimization of management planning, which in turn may adversely influence patient prognosis.

Conditions

• Metastasis

Interventions

Type	Name	Description
DEVICE	PET/CT	Patient preparation: Patients will fast for 4 - 6 h before PET scanning to optimize the blood sugar level to 160mg/dl. F-18 FDG dose was 0.14 mCi/kg and injected via intravenous route. During the uptake phase of 18F-FDG patients will be rested in a quite warm room. Procedure: All PET-CT studies will be done at the nuclear medicine unit in Assuit University Hospital. PET-CT images will be interpreted at a workstation equipped with fusion software that offers multi-planar reformatted images and enables display of the PET images, CT images, and fused PET/CT images.

Timeline

• Start date: 2023-10-01
• Primary completion: 2026-09-01
• Completion: 2026-12-01
• First posted: 2023-09-28
• Last updated: 2023-09-28