NCT06051110

Individual Patient Data Meta-analysis on Prehospital Risk Assessment in Patients Suspected of Non-ST-segment Elevation Acute Coronary Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 5,239 (actual)
• Sponsor: Catharina Ziekenhuis Eindhoven · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Patients with a non-ST-segment elevation acute coronary syndrome (NSTE-ACS) are currently transported and admitted to the nearest emergency department (ED) for risk stratification, diagnostic workup, and treatment. Recently, several prospective studies have been performed on the diagnostic performance of point-of-care (POC)-troponin and combined risk scores (CRS) for pre-hospital risk assessment and triage of NSTE-ACS patients. Also the first intervention trials on triage decisions based on POC troponin and CRS have been performed. Initial results are indicating that prehospital triage based on these diagnostic tools is feasible and safe, although sample sizes were relatively small and underpowered to detect differences in major adverse cardiac events (MACE). The objective of this individual patient data meta-analysis is to determine the diagnostic performance of POC troponin and combined risk scores for prehospital risk assessment and triage in suspected NSTE-ACS patients.

Conditions

• Acute Coronary Syndrome
• Non ST Segment Elevation Acute Coronary Syndrome

Interventions

Type	Name	Description
DEVICE	Combined risk score	Prehospital risk stratification by the use of a combined clinical risk score including POC-troponin
OTHER	Usual care	Prehospital risk stratification by EMS protocols
DEVICE	point-of-care troponin	Prehospital risk stratification by the use of a POC-troponin

Timeline

• Start date: 2023-10-01
• Primary completion: 2024-12-01
• Completion: 2026-01-01
• First posted: 2023-09-22
• Last updated: 2026-03-18

Locations

1 site across 1 country: Netherlands