NCT06047119

Respiratory and Hemodynamic Targets During General Anesthesia

Respiratory and Hemodynamic Targets During General Anesthesia - A Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 485 (actual)
• Sponsor: Lars Wiuff Andersen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This trial is an investigator-initiated, multicenter, randomized, factorial, single-blind trial of multiple hemodynamic and respiratory targets during general anesthesia. These targets include blood pressure, positive end expiratory pressure, tidal volume, and fraction of inspired oxygen. Patients will be randomized to different targets using a factorial design, i.e., each patient is simultaneously randomized to four interventions. There will be five enrolling sites in the Central Denmark Region. 480 high-risk patients will be enrolled.

Conditions

• Patients Undergoing General Anesthesia

Interventions

Type	Name	Description
PROCEDURE	Blood pressure	Blood pressure targets during general anesthesia and 2 hours after
PROCEDURE	Positive end expiratory pressure	Positive end expiratory pressure during general anesthesia
PROCEDURE	Tidal volume	Tidal volume during general anesthesia
PROCEDURE	Fraction of inspired oxygen	Fraction of inspired oxygen during general anesthesia and 2 hours after

Timeline

• Start date: 2023-10-09
• Primary completion: 2025-04-24
• Completion: 2025-04-24
• First posted: 2023-09-21
• Last updated: 2025-08-05

Locations

6 sites across 1 country: Denmark