NCT06045650

Relationship Between Oxytocin Level, Trust, and Attachment in Individuals With Borderline Personality Disorder

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 92 (estimated)
• Sponsor: State University of New York - Upstate Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

We aim to assess the baseline oxytocin levels in individuals with borderline personality disorder and correlate those levels with social behavior, and compare the results with controls. Primary Hypothesis (H1): There is a significant difference in trust-related behavior as measured by oxytocin (OXT) levels between borderline personality disorder (BPD) patients and healthy controls. Secondary Hypotheses: H2: The trust-related behavior in BPD patients is significantly influenced by their level of emotional sensitivity. Specifically, higher emotional sensitivity in BPD patients is associated with lower trust-related behavior and vice-versa. H3: There is a significant correlation between trust-related behavior and childhood trauma in BPD patients. BPD patients with higher levels of reported childhood trauma will exhibit lower trust-related behavior compared to those with lower levels of trauma. H4: Trust-related behavior in BPD patients varies depending on their attachment styles. Specifically, BPD patients with insecure attachment styles will exhibit lower trust-related behavior compared to those with secure attachment styles. H5: There is a significant correlation between trust-related behavior and BPD severity. Patients with more severe BPD symptoms will exhibit lower trust-related behavior compared to those with less severe symptoms. H6: The levels of OXT in BPD patients will significantly correlate with their reported levels of emotional sensitivity, childhood trauma, attachment styles, and BPD severity. These hypotheses aim to address the complexities surrounding the modulation of trust-related behavior by oxytocin in BPD patients, taking into account various factors like emotional sensitivity, childhood adversity, attachment styles, and BPD severity. By testing these hypotheses, the study aims to provide a comprehensive understanding of the interplay between these factors in influencing trust-related behavior in BPD patients.

Conditions

• Borderline Personality Disorder

Interventions

Type	Name	Description
OTHER	baseline serum oxytocin levels	Both cases and controls will be assessed for their baseline serum oxytocin levels
OTHER	Emotional Sensitivity test	To assess the level of emotional sensitivity in the participant
OTHER	Neuro-economical game	A game played to assess the trust-index of participants
OTHER	Childhood Trauma Questionnaire	to assess childhood trauma score
OTHER	Relationships Questionnaire	to assess attachment type
OTHER	demographic questionnaire	To obtain basic data on demographics

Timeline

• Start date: 2024-06-01
• Primary completion: 2025-08-01
• Completion: 2025-09-01
• First posted: 2023-09-21
• Last updated: 2024-05-24

Locations

1 site across 1 country: United States