NCT06044415

Brain Activity Under the Influence of JWH

Brain Kinetics of Neurotransmission During JWH-018 Intoxication

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Maastricht University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The goal of this placebo-controlled study is to learn about the neural mechanisms underlying the acute effects of the synthetical cannabinoid JWH-018 in healthy, occasional cannabis users. It aims to assess neural underpinnings of neurocognitive impairments and psychotomimetic symptoms expected during the intoxication. Neuronal changes similar to those seen in cannabis intoxication are expected, such as altered neurotransmission and loss of functional connectivity within the mesocorticolimbic circuit. MRS, fMRI and blood parameters will be used for assessment. Participants will be asked to complete cognitive tasks and subjective questionnaires related to the subjective experience of the drug.

Conditions

• Neurotransmission During JWH Intoxication

Interventions

Type	Name	Description
DRUG	JWH018	A vaporized dose of 7.5 mg of JWH-018 will be inhaled by the participants
OTHER	non-active control (no substance)	Participants will inhale from a vaporizer with an empty chamber.

Timeline

• Start date: 2023-10-01
• Primary completion: 2024-10-01
• Completion: 2024-10-01
• First posted: 2023-09-21
• Last updated: 2023-09-21