NCT06044051

Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma

Dynamique Des Microbiomes Respiratoires Des Voies supérieures et inférieures associée à l'Asthme sévère Des Nourrissons

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University Hospital, Rouen · Academic / Other
• Sex: All
• Age: 24 Months
• Healthy volunteers: Not accepted

Summary

Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evolution under treatment. Exploring and understanding these data is to improve patient care and discover new therapeutic targets. The aim is to open up prospects for therapeutic studies, such as the use of azithromycin as an immunomodulator in infant asthma, the results of which are discordant.

Conditions

• Asthma in Children
• Asthma

Interventions

Type	Name	Description
OTHER	Blood sample	An additionnal volume of blood will be collected at inclusion and at each follow-up visit
OTHER	Expectoration	Expectoration will be collected at inclusion and at each follow-up visit
OTHER	Nasopharyngeal swab	A nasopharyngeal swab will be collected at inclusion and at each follow-up visit after an induced sputum

Timeline

• Start date: 2023-09-26
• Primary completion: 2026-09-26
• Completion: 2026-09-26
• First posted: 2023-09-21
• Last updated: 2026-02-17

Locations

1 site across 1 country: France