NCT06043310

Estrogen and Microvascular Function

Effects of Continuous Estrogen on Human in Vivo Microvascular Function

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 45 (estimated)
• Sponsor: Medical College of Wisconsin · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to learn how long-term use of estrogen affects blood vessels in healthy adults. Participants will: * give one blood draw of 5 mL * have one Dexa Scan taken to measure adipose and muscle mass * have a camera placed under the tongue to take pictures of blood vessels * have 2 laser Doppler microdialysis catheters placed on the forearm to monitor blood vessels before and after local drug infusion Researchers will compare blood vessel function of those who take estrogen to those who do not.

Conditions

• Estrogen
• Cardiovascular Diseases
• Microvasculature
• Oral Contraceptive Use

Interventions

Type	Name	Description
DRUG	Nω-nitro-L-arginine methyl ester (L-NAME)	L-NAME will be infused locally through microdialysis catheters.
DRUG	Acetylcholine	ACh will be infused locally through microdialysis catheters.
DRUG	Sodium Nitroprusside	SNP will be infused locally through microdialysis catheters.

Timeline

• Start date: 2023-10-12
• Primary completion: 2031-12-01
• Completion: 2031-12-01
• First posted: 2023-09-21
• Last updated: 2025-07-04

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study