NCT06043076

iTBS Effect on M1 Plasticity, Blood Glucose, and Cardiovascular Response

The Effect of Intermittent Theta-Burst Stimulation on Motor Cortical Plasticity, Blood Glucose, and Cardiovascular Response in Healthy Young Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Universiti Putra Malaysia · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols. Among these, intermittent theta-burst stimulation (iTBS) is a novel protocol that enhances the M1 excitability for several minutes beyond stimulation. The changes in M1 excitability might in turn be accompanied by other physiological responses in the human body. This study will explore the effect of iTBS protocol on M1 plasticity, heart rate, blood pressure, and blood glucose in healthy young adults in comparison to sham stimulation.

Conditions

• Healthy Young Adults

Interventions

Type	Name	Description
DEVICE	TMS	Active iTBS will be applied using a butterfly figure-of-eight C-B60 coil connected to MagPro R30 stimulator with add-on Theta Burst option (MagVenture A/S, Farum, Denmark).
DEVICE	Sham	Sham iTBS will be applied using acoustic stimulation of a second coil behind the participant's head

Timeline

• Start date: 2023-07-01
• Primary completion: 2024-01-01
• Completion: 2024-01-01
• First posted: 2023-09-21
• Last updated: 2024-04-02

Locations

1 site across 1 country: Malaysia