NCT06041867

Agaricus Bisporus and Influenza Vaccination Response

Mushboost: Evaluating the Effect of Agaricus Bisporus Powder Intake on the Vaccination Response to an Influenza Vaccine

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 88 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 59 Years
• Healthy volunteers: Accepted

Summary

There are numerous in vitro and animal studies that suggested that mushrooms beneficially influence the immune system. We have recently shown that a wild isolate of the edible Agaricus bisporus mushroom had a clear effect on parameters reflecting a better function of the immune system, both in vitro and in vivo in animals. The question now is whether this efficacy can also be translated to humans. In humans, measuring the antibody response is the golden standard to evaluate immune function. If Agaricus bisporus powder indeed has beneficial effects on the immune system, people with overweight or obesity and higher age might benefit from consuming Agaricus bisporus powder prior to receiving the influenza vaccination.

Conditions

• Immune Response

Interventions

Type	Name	Description
BIOLOGICAL	Influenza vaccine	Single dose of the Influenza vaccine Participants have to wait until they are invited to receive the vaccine by the general practitioner; this study does not interfere with national planning of the vaccine
DIETARY_SUPPLEMENT	Agaricus bisporus capsules	Participants have to consume 10 capsules per day containing 500 mg Agaricus bisporus powder each, corresponding to a total Agariicus bisporus powder intake of 5 g daily
DIETARY_SUPPLEMENT	Control capsules	Participants have to consume 10 capsules per day containing 500 mg maltodextrin each, corresponding to a total maltodextrin intake of 5 g daily

Timeline

• Start date: 2023-09-14
• Primary completion: 2023-12-15
• Completion: 2024-05-30
• First posted: 2023-09-18
• Last updated: 2025-03-24

Locations

1 site across 1 country: Netherlands