NCT06041087

Bone and Inflammatory Outcomes - Nutrition and Exercise Trials

Dairy Supplementation and the Post-Exercise Bone and Inflammatory Response

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: York University · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This study investigates whether dairy products will positively impact loading exercise-induced bone turnover and bone cell activity and/or the post-exercise inflammatory response in healthy young adults compared to a carbohydrate drink and/or water.

Detailed description

Introduction: Two million individuals at a cost of around 4.6 billion dollars a year in Canada suffer from osteoporosis. It is important to investigate strategies that can reduce bone loss and/or increase bone mass. Similarly, inflammation is associated with many different disease states, and investigating strategies to reduce systemic inflammation is prudent. Nutrition and exercise may be inexpensive and accessible strategies to improve bone health and inflammation and should be explored in different contexts and implemented. Our proposed research combines both nutrition and exercise along with the assessment of bone turnover and inflammatory markers in healthy young adults. Design: Randomized controlled crossover trial Participants: Healthy, university aged males and females. Methods: During the study participants will complete 4 different acute exercise and nutritional supplement trials, in random order. The four trials are: 1) exercise+carbohydrate (CHO), 2) exercise+milk (Milk), 3) exercise+Greek yogurt (GY), and 4) exercise+water (W). The whole study will take a maximum of 16 weeks and each supplement trial will be separated by 2-4 weeks. Outcomes: several markers of bone turnover and bone cell activity as well as markers of inflammation will be measured in the blood, before exercise and at different times post-exercise and post supplement consumption.

Conditions

• Healthy
• Bone
• Inflammation

Interventions

Type	Name	Description
BEHAVIORAL	High-Intensity Exercise	A single bout of high-intensity exercise (cycling intervals, resistance exercise, plyometrics) per trial.
DIETARY_SUPPLEMENT	Carbohydrate (Maltodextrin powder mixed with water)	50g consumed immediately after exercise and 1h after exercise.
DIETARY_SUPPLEMENT	Skim Milk	500ml consumed immediately after exercise and 1h after exercise.
DIETARY_SUPPLEMENT	Greek yogurt	200g consumed immediately after exercise and 1h after exercise.
DIETARY_SUPPLEMENT	Water	500ml consumed immediately after exercise and 1h after exercise.

Timeline

• Start date: 2023-11-01
• Primary completion: 2025-04-30
• Completion: 2025-09-01
• First posted: 2023-09-18
• Last updated: 2026-01-16

Locations

1 site across 1 country: Canada