NCT06036589

Characterization of Bovine Adrenal Medulla as a Model of Non-histaminergic Itch

Characterization of Bovine Adrenal Medulla (BAM8-22) as a New Surrogate Model of Non-histaminergic Itch

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

With this experiment, the experimenter wish evaluate the role of TRPA1 on non-histaminergic itch induced by BAM8-22

Detailed description

With this experiment, the experimenter wish evaluate the role of TRPA1 on non-histaminergic itch induced by BAM8-22 2 (Bovine Adrenal Medulla), which is found naturally in the human body and which has proved to evoke itch. To evaluate the role of TRPA1 it will be used a TRPA1 agonist

Conditions

• Itch

Interventions

Type	Name	Description
DRUG	CA and BAM8-22	CA (tran-cinnamaldheyde) solution (in ethanol 5%) application and BAM8-22 with inactivate cowhage spicules 20 µl of BAM8-22 will be applied to a previously determined area on the volar forearm using inactivate cowhage spicules
DRUG	Vehicle and BAM8-22 application	Vehicle (ethanol) application and BAM8-22 with inactivate cowhage spicules 20 µl of BAM8-22 will be applied to a previously determined area on the volar forearm using inactivate cowhage spicules
DRUG	CA	CA (tran-cinnamaldheyde) solution (in ethanol 5%) application to a previously determined area on the volar forearm
DRUG	vehicle	Vehicle (ethanol) application and inactivate cowhage spicules will be applied to a previously determined area on the volar forearm

Timeline

• Start date: 2022-03-10
• Primary completion: 2022-05-30
• Completion: 2022-10-30
• First posted: 2023-09-14
• Last updated: 2023-09-14

Locations

1 site across 1 country: Denmark