NCT06036524

Multi-modal Imaging of Myofascial Pain

Development and Identification of Magnetic Resonance, Electrophysiological, and Fiber-optic Imaging Biomarkers of Myofascial Pain

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to develop new imaging biomarkers for quantitative assessments of myofascial pain.

Detailed description

This study aims to develop a multi-modal, multi-parametric, multi-scale imaging of the human myofascial unit by combining magnetic resonance imaging (MRI), surface electromyography (sEMG), and fiber-optic imaging and sensing. Participants (half with active neck/shoulder/back pain, and half healthy controls) will be recruited from pain management clinics and Volunteer for Health, or will be referred by Dr. Xioabin Yi. They will undergo all three imaging techniques and complete a number of patient questionnaires over the course of a single study visit. The study team will then identify candidate biomarkers capable of differentiating between healthy (no myofascial pain) and those with active pain to target in a future clinical trial.

Conditions

• Myofascial Pain

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Multi-modal, multi-parametric, multiscale imaging of the myofascial unit	Study Participants will undergo four study procedures at one visit, including magnetic resonance imaging (MRI), surface electromyography (sEMG), fiber-optic imaging and sensing, and questionnaires.

Timeline

• Start date: 2023-10-24
• Primary completion: 2025-04-30
• Completion: 2026-04-30
• First posted: 2023-09-14
• Last updated: 2025-12-17

Locations

1 site across 1 country: United States