Trials / Completed
CompletedNCT06035081
CIRcadian Rhythms and CortisoL. Effects on Substrate Metabolism and Clock Gene Expression and Functioning
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 10 (actual)
- Sponsor
- University of Aarhus · Academic / Other
- Sex
- Male
- Age
- 18 Years – 45 Years
- Healthy volunteers
- Accepted
Summary
The aim of this project is to study the effects of exogenous glucocorticoid exposure on substrate metabolism, energy expenditure and correlates of circadian rhythmicity in healthy adults. The hypotheses are: Short-term high dose glucocorticoid exposure in healthy subjects disrupts: * The inherent circadian pattern of the respiratory exchange ratio and REE * Sleep quality, appetite and food intake * Clock gene expression and function in adipose tissue, skeletal muscle and blood leukocytes
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Prednisolone | see arm description |
| OTHER | Placebo | Placebo similar to prednisolone |
Timeline
- Start date
- 2023-09-15
- Primary completion
- 2024-04-13
- Completion
- 2024-12-01
- First posted
- 2023-09-13
- Last updated
- 2025-04-04
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT06035081. Inclusion in this directory is not an endorsement.