NCT06034626

Therapeutic Effectiveness of Different Machines in Intense Pulsed Light Treatment of Meibomian Gland Dysfunction

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 216 (actual)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to determine the therapeutic effectiveness of different machines in intense pulsed light (IPL) treatment of meibomian gland dysfunction (MGD). Subjects diagnosed with MGD underwent three sessions of IPL treatment in a control (M22) treatment group or experimental (OPL-I) treatment group and were followed up three to four weeks after each session. Tear breakup time (TBUT), meibomian gland secretion scores (MGSS), meibomian gland meibum scores (MGMS), corneal fluorescein staining (CFS) scores, and the Standard Patient Evaluation of Eye Dryness (SPEED) was used to assess eye dryness signs and symptoms at baseline and follow-up visits.

Conditions

• MGD-Meibomian Gland Dysfunction

Interventions

Type	Name	Description
PROCEDURE	Intense pulsed light	Each MGD patient underwent three treatment sessions at three-week intervals and three follow-up examinations over the course of treatment.
DRUG	0.3% hyaluronic acid eye drops	0.3% hyaluronic acid eye drops (Hialid; Santen, Osaka, Japan) four times a day during the study, including the follow-up period.

Timeline

• Start date: 2020-11-03
• Primary completion: 2021-08-10
• Completion: 2021-12-15
• First posted: 2023-09-13
• Last updated: 2023-09-13

Locations

3 sites across 1 country: China