NCT06033807

Active Screening of Latent Tuberculosis Infection in School Contacts of Active Tuberculosis Patients

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 31,440 (estimated)
• Sponsor: Huashan Hospital · Academic / Other
• Sex: All
• Age: 13 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to investigate the proportion of Mycobacterium tuberculosis (MTB) infection in school contacts of active tuberculosis (ATB) patients. The main questions it aims to answer are: * the proportion of MTB infection among school contacts of ATB patients * risk factors related to tuberculosis (TB) infection * health economic evaluation of screening strategy

Conditions

• Tuberculosis
• Latent Tuberculosis Infection

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	QuantiFERON-TB Gold (QFT) test	Participants will be tested by QuantiFERON-TB Gold (QFT) test to see if they have ever infected by MTB. Those with positive results will proceed to sputum Xpert MTB/RIF, physical examination and chest CT scan, as well as sputum culture if necessary to distinguish latent TB infection (LTBI) from ATB. X-ray scan is conditional on age above 15 years with a positive QuantiFERON-TB Gold (QFT) test result.

Timeline

• Start date: 2023-09-01
• Primary completion: 2025-09-01
• Completion: 2025-12-31
• First posted: 2023-09-13
• Last updated: 2025-04-01

Locations

44 sites across 1 country: China