NCT06033222

A Study of Perturbation of Human Small Intestinal Colonic Permeability

Developing an Approach to Perturbation of Human Small Intestinal and Colonic Permeability in Healthy Participants

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate the effect of castor oil versus placebo on intestinal permeability in healthy individuals.

Detailed description

Randomized, parallel-group, placebo-controlled, blinded, dose-response study using Castor oil and see the effects it has on small bowel and colonic permeability measured in healthy female and male adults.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ricinoleic Acid 750 mg	750 mg administered orally
DIETARY_SUPPLEMENT	Ricinoleic Acid 1500 mg	1500 mg administered orally
DIETARY_SUPPLEMENT	Ricinoleic Acid 3000 mg	3000 mg administered orally
DRUG	Placebo	Contains no active ingredient.

Timeline

• Start date: 2024-01-08
• Primary completion: 2024-05-23
• Completion: 2024-07-31
• First posted: 2023-09-13
• Last updated: 2024-09-19

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study