NCT06033144

Prevalence of Tapia's Syndrome in Weaning Unit

Prevalence of Tapia's Syndrome in Weaning Unit and Associated Factors After Orotracheal Intubation in the ICU

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 247 (estimated)
• Sponsor: Hopital Forcilles · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Tapia syndrome is a rare and poorly understood pathology. It is defined by a concomitant attack of the recurrent (branch of X) and hypoglossal (XII) nerves of peripheral or central origin. It is characterized by the paralysis of a vocal cord and the ipsilateral half of tongue. This damage is most often unilateral but it can also be bilateral. It results in dysphonia and swallowing disorders. Tapia syndrome is a rare and poorly understood pathology. To date, less than 100 cases have been described in the literature. Previous works are mainly case reports and literature reviews. No prevalence study has been performed to date. Furthermore, disagreements persist regarding the semiology. Indeed, the involvement of the soft palate is not always described.

Detailed description

The main aim of this study was to determine the prevalence of Tapia syndrome in patients admitted to weaning unit after prolonged (\>48h) orotracheal intubation in the ICU. The secondary objectives are to: * Describe the clinical semiology of Tapia syndrome : lingual involvement, soft palate involvement, impairment of phonation and swallowing ; * Describe the paraclinical features of Tapia syndrome: recurrent involvement, laryngeal and lingual involvement; * Identify factors associated with Tapia's syndrome

Conditions

• Tapia's Syndrome

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Diagnosis of Tapia's Syndrome	The diagnostic includes : * Lingual clinical examination * Nasofibroscopy * Ultrasonography

Timeline

• Start date: 2023-04-07
• Primary completion: 2025-11-07
• Completion: 2027-04-07
• First posted: 2023-09-13
• Last updated: 2025-09-15

Locations

1 site across 1 country: France