NCT06032338

Trial of Direct Home Delivery of Colorectal Cancer Screening Kit Without Pre-ordering

EXPérimentation d'Envoi Postal DIrect à Domicile du kiT de dépistage du Cancer Colorectal Sans Commande préalable [Trial of Direct Home Delivery of Colorectal Cancer Screening Kit Without Pre-ordering]

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 64,000 (estimated)
• Sponsor: University Hospital, Caen · Academic / Other
• Sex: All
• Age: 50 Years – 74 Years
• Healthy volunteers: Not accepted

Summary

The effect of mailing FIT with the invitation on participation and colonoscopy rates will be evaluated in a randomized controlled trial conducted in the Centre-Val de Loire (CVL) region, involving 64,000 people from the population eligible for colorectal cancer population-based organised screening program (CRC-PBOSP). In the "C" control group, invitations, test delivery and reminders will be carried out in accordance with the CRC-PBOSP rules at the time of the study. Intervention group "B" will evaluate two experimental modes of invitation with direct home mailing of the test: * Method "B1": invitation with test sent to home without prior information letter * Method "B2": information letter followed by invitation with test sent home, designed to optimize participation by first-time subjects (aged 50-51) invited to the CRC-PBOSP for the first time. Ancillary studies will focus 1/ on acceptability of this intervention (qualitative study on a few general practitioners, gastroenterologists and invitees), 2/ on social and geographical inequalities of participation on a subsample of individuals included in EXPEDIT study using ecological indices (EDI, SCALE).

Conditions

• Colorectal Cancer

Interventions

Type	Name	Description
OTHER	CRC screening invitation not including the screening test.	The invitation to CRC-PBOSP will only contain informations on how to get the screening test.
OTHER	Mailing of FIT with invitation	The invitation to CRC-PBOSP will contain the CRC screening test.
OTHER	Information letter before invitation	An information letter will be sent to future invitees a few weeks before the invitation, to announce the mailing of the CRC screening kit.

Timeline

• Start date: 2023-09-14
• Primary completion: 2026-04-14
• Completion: 2026-11-14
• First posted: 2023-09-13
• Last updated: 2026-03-18

Locations

1 site across 1 country: France