NCT06031168

1% Metformin Gel-coated Implants and Osteointegration and Crestal Marginal Bone Loss

Evaluation the Effect of Topically Coated Dental Implants With 1% Metformin Gel on Osteointegration and Crestal Marginal Bone Loss (a Randomized Controlled Clinical Trial)

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (estimated)
• Sponsor: Hams Hamed Abdelrahman · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Achieving and maintaining a long term osseointegrated dental implant is a golden goal of success in field of dentistry. Osteointegration depends on surface treatment of dental implants. various techniques of implant coating have been introduced to enhance and accelerate osteointegration. The purpose of present study is to clinically and radiographically evaluate the osseointegration around hydrophilic dental implants coated with 1% Metformin gel Materials and Methods: We executed a randomized controlled clinical trial. The sample will include patients demanding dental implant treatment. Patients will be randomly allocated into the two groups of the study. The group A will be treated with 1% concentrated metformin gel coated hydrophilic dental implant. Group B will be treated with uncoated hydrophilic dental implant. The primary outcome variable will be implant osteointegration and crestal marginal bone loss around implants. It will be measured at time of implant placement and reevaluated after 4, 6-months with periapical x-ray and 3-dimensional imaging.

Conditions

• Osteointegration

Interventions

Type	Name	Description
OTHER	Metformin gel coated implants	Patients will be treated with 1% concentrated metformin gel coated hydrophilic dental implant.
OTHER	uncoated hydrophilic dental implants	Patients treated by uncoated implants

Timeline

• Start date: 2023-09-04
• Primary completion: 2023-11-30
• Completion: 2023-11-30
• First posted: 2023-09-11
• Last updated: 2023-09-11

Locations

1 site across 1 country: Egypt