NCT06031090

Clonidine Versus Granisetron for Shivering Prevension

Intravenous Clonidine Versus Granisetron for Prevention of Post Spinal Anesthesia Shivering in Cesarean Section

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 186 (estimated)
• Sponsor: Zagazig University · Other Government
• Sex: Female
• Age: 21 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Prevention of post spinal anesthesia shivering during cesarean section with its associated discomfort, distress, aggravation of pain, increased metabolic demands, and increased oxygen consumption

Detailed description

Shivering is one of the most important periperative complications seen in clinical practice. Several mechanisms have been postulated for its pathogenesis. Anesthetic-induced inhibition of thermoregulation resulting in hypothermia is an important cause of post anesthesia shivering, uncontrolled spinal reflexes, and cutaneous vasodilation are the other suggested mechanisms involved in the pathogenesis of shivering. Opioid receptors, α2 receptors, and serotonergic receptors also are involved of shivering. Various drugs were studied for their potential role in prevention of peri-operative shivering such as tramadol, dexmedetomidine, ondansetron, ketamine, and pethidine. We decided to perform a well-designed study to compare clonidine and granisetron which has been recently introduced as drugs for prevention and control of shivering after spinal anesthesia.

Conditions

• Post Spinal Anesthesia Shivering

Interventions

Type	Name	Description
DRUG	Clonidine Injection	intravenous Clonidine 0.5 µg/kg diluted in 10ml normal saline 20 minutes before spinal anesthesia
DRUG	Granisetron Injection	intravenous 1mg of granisetron diluted in 10ml normal saline 20 minutes before spinal anesthesia.
DRUG	Normal Saline 10 mL Injection	intravenous 10 ml normal saline 20 minutes before spinal anesthesia

Timeline

• Start date: 2023-03-05
• Primary completion: 2023-10-05
• Completion: 2023-10-30
• First posted: 2023-09-11
• Last updated: 2023-09-11

Locations

1 site across 1 country: Egypt