NCT06030726

Nationwide Utilization of Danish Government Electronic Letter System for Confirming the Effectiveness of Behavioral Nudges in Increasing InFLUenza Vaccine Uptake Among Older Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 881,373 (actual)
• Sponsor: Tor Biering-Sørensen · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

In randomized clinical trials and observational studies, influenza vaccination has been shown to be effective in reducing influenza-related illness, hospitalizations, cardiovascular events, and mortality in select populations. However, the real-world effectiveness of influenza vaccination is limited by its uptake. Conducted during the 2022/2023 influenza season, the first NUDGE-FLU trial demonstrated the effectiveness of two electronic behavioral nudging letter strategies in increasing influenza vaccination rates among older adults in Denmark - a letter highlighting potential cardiovascular benefits of vaccination and a standard informational letter sent at baseline and repeated at day 14. This present study will once again investigate whether digital behavioral nudges delivered via the official, mandatory Danish electronic letter system can increase influenza vaccine uptake among older adults including whether the effectiveness of previously successful strategies can be confirmed during a subsequent influenza season.

Detailed description

The study is a prospective, randomized, open-label implementation trial. The study population will consist of persons aged \>=65 years at January 15, 2024 - this age group is eligible for free-of-charge influenza vaccination in the official Danish vaccination program. Subjects will be identified through Danish nationwide health registries including the Danish Civil Registration System. Individuals will be randomized to 1 of 7 arms (1 usual care arm and 6 intervention arms) with each testing different nudging strategies employing various behavioural economic principles. The interventions will be delivered through the official, mandatory Danish electronic letter system. All subject data will be retrieved from the Danish nationwide registries with the exception of information on intervention allocation. Endpoints will be retrieved at prespecified dates using prespecified search algorithms.

Conditions

• Influenza
• Behavior and Behavior Mechanisms

Interventions

Type	Name	Description
BEHAVIORAL	Behavioral Economic Principles	The control arm will receive no letter to reflect the background vaccination uptake. Intervention arms will test the effects of different letters developed using behavioral economic principles.

Timeline

• Start date: 2023-09-14
• Primary completion: 2024-01-01
• Completion: 2024-05-31
• First posted: 2023-09-11
• Last updated: 2024-10-10

Locations

1 site across 1 country: Denmark