NCT06029634

Effects of T-bet B Cells in Persistent Virus Control After Discontinuance of NAs in CHB Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 45 (actual)
• Sponsor: Changhai Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The immune mechanism of the nucleos(t)ide analogs (NAs) in inhibiting HBV replication effectively while having a low sustained virus control rate after drug withdrawal is unclear. B cell immunity and antibody response are the keys to prevent HBV reinfection and keep the virus under control. T-bet+ B, which can be regulated by IL-21, is a newly discovered major effector B cell in protection of pathogens and it is a main subtype of HBsAg-specific B cells. Thus, we suspect that T-bet+ B may play a role in ongoing controlling of the virus after withdraw of NAs in CHB patient. Based on our previous studies on CHB immunity, we use the RNAseq analyse, flow cytometry, and Elispot assay to analyze the frequency, function, and phenotype of B cells in CHB patients with different profiles after withdraw of NAs.

Conditions

• Chronic HBV Infection
• Drug Withdrawal

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	T-bet B cell	The frequency, function, and phenotype of T-bet B cells was tested

Timeline

• Start date: 2020-07-01
• Primary completion: 2023-08-10
• Completion: 2023-08-20
• First posted: 2023-09-08
• Last updated: 2023-09-08

Locations

1 site across 1 country: China