NCT06028165

CABG Based on CT-FFR Versus Conventional Coronary Angiography

A Prospective, Randomized Comparison of Coronary Artery Bypass Grafting Based on COmputed Tomography-derived Fractional Flow REserve Versus Angiography (CABG-COREA Trial)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 96 (estimated)
• Sponsor: Myongji Hospital · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The aims of study are (1) to compare early and 1-year graft patency rates in patients who underwent coronary artery bypass grafting (CABG) based on conventional coronary angiography(CAG) versus cardiac computed tomography(CT)-derived fractional flow reserve(FFR), and (2) to demonstrate difference in clinical outcomes between the 2 groups.

Detailed description

The CABG-COREA trial is designed as a randomized, controlled trial to recruit 96 patients who undergo coronary artery bypass grafting. Patients were randomized by use of a randomization table. Coronary arteries are revascularized based on conventional coronary angiography (quantitative coronary angiography) or cardiac computed tomography-derived fractional flow reserve according to the randomization result. The primary end point is to evaluate early and 1-year postoperative graft patency. The secondary end points are overall survival, freedom from cardiac death and freedom from MACCE(major adverse cardiac or cerebrovascular events).

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
PROCEDURE	Coronary artery bypass grafting based on conventional coronary angiography	Revascularized coronary arteries are decided based on conventional coronary angiography (quantitative coronary angiography)
PROCEDURE	Coronary artery bypass grafting based on cardiac computed tomography-derived fractional flow reserve.	Revascularized coronary arteries are decided based on cardiac computed tomography-derived fractional flow reserve.

Timeline

• Start date: 2023-10-20
• Primary completion: 2024-10-01
• Completion: 2025-10-01
• First posted: 2023-09-08
• Last updated: 2024-07-05

Locations

1 site across 1 country: South Korea