NCT06027320

The Retain Your Brain Health Study (RetainYourBrain.com)

Risk Education Technology As Individualized Neuroprotection

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 992 (actual)
• Sponsor: Retain Health, Inc · Academic / Other
• Sex: All
• Age: 53 Years – 105 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to test a cell phone-based online program that provides Alzheimer's risk assessments and memory tests over a 6-month period. The main question it aims to answer is whether online software can help reduce the risk of Alzheimer's disease (AD) through digital education and tracking. Participants will visit RetainYourBrain.com to answer questions about their risk factors for AD and take online word recall and card game cognitive tests. Researchers will track progress over time and compare different strategies of Alzheimer's education to see if it is possible to protect brain health, reduce Alzheimer's risk, and improve memory function.

Detailed description

Alzheimer's disease (AD) is a public health crisis with few effective treatments. Most people are unaware that AD begins in the brain decades before the first symptoms of memory loss begin. That leaves a lot of time for people to learn their individual risk factors for AD and cognitive decline and take memory assessment screening tests in an effort toward the prevention or delay of dementia. To reach a growing at-risk population, mobile health technologies accessible via cell phone can fill an unmet need due to their accessibility and cost-effective delivery of care. Online education and text messaging have proven to be effective methods of reducing risk for a variety of chronic conditions, including cardiovascular disease and diabetes, which are both key drivers of AD risk. The investigators created a cell phone-based online software application to provide automated, individualized monitoring and education at broad scale. The goal of the software is to function as a digital therapeutic to identify individual risk factors, assess memory and cognitive function over time, and provide education to people with a family history of AD. The system maintains bi-directional communication via text message to verify participant engagement. Potential participants who visit our study website (www.RetainYourBrain.com) will be directed to answer questions assessing eligibility criteria. Participants who are eligible are asked to electronically sign an informed consent form, complete baseline assessments, and take online word recall and card game cognitive tests. Participants will then be randomized to one of two groups using different strategies for AD risk assessment education. Researchers will track progress over six months and compare different strategies of education to determine if it is possible to protect brain health, reduce Alzheimer's risk, and improve memory function.

Conditions

• Alzheimer Disease
• Dementia
• Healthy Participants
• Brain Health

Interventions

Type	Name	Description
BEHAVIORAL	Brain Health Education	Subjects will receive an Alzheimer's risk assessment, memory testing, and brain health education, in addition to text message communication.
BEHAVIORAL	Alzheimer Disease Education	Subjects will receive an Alzheimer's risk assessment, memory testing, and general education about Alzheimer's disease, in addition to text message communication.

Timeline

• Start date: 2023-12-07
• Primary completion: 2024-09-16
• Completion: 2024-09-16
• First posted: 2023-09-07
• Last updated: 2024-11-01

Locations

1 site across 1 country: United States