NCT06025357

Effects of L-citrulline Supplementation on Vascular Function in Metabolic Syndrome

Effects of L-Citrulline Supplementation on Vascular Function During Fasted and Acute Hyperglycemia in Middle-aged and Older Women With Metabolic Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Texas Tech University · Academic / Other
• Sex: Female
• Age: 45 Years – 79 Years
• Healthy volunteers: Accepted

Summary

The objective of this project is to provide evidence that L-Citrulline (CIT) supplementation can improve vascular function in the fasted and acute hyperglycemia conditions in middle-aged and older women with metabolic syndrome.

Detailed description

Using a double-blind, randomized, placebo-controlled, and parallel design, middle-aged and older women with metabolic syndrome will be randomized into receiving either CIT supplementation (10g/day) or placebo (Microcrystalline Cellulose) for 4 weeks. The first visit will be approximately 1hr and 30 minutes. The 2nd and 3rd visits will each be approximately 2hrs and 30 minutes, separated by 4 weeks in between each visit. During visits 2 and 3, vascular measurements will be assessed in the fasted state and 30, 60, and 90 minutes after acute glucose ingestion (75g).

Conditions

• Metabolic Syndrome
• Menopause

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	L-Citrulline supplementation	4 weeks of L-Citrulline supplementation (10 grams/day).
DIETARY_SUPPLEMENT	Placebo	4 weeks of microcrystalline Cellulose supplementation.

Timeline

• Start date: 2023-01-01
• Primary completion: 2024-05-01
• Completion: 2024-08-01
• First posted: 2023-09-06
• Last updated: 2025-05-15

Locations

1 site across 1 country: United States