Trials / Completed
CompletedNCT06023433
Impact of Gingival Crevicular Fluid microRNAs on Orthodontic Tooth Movement
Impact of Gingival Crevicular Fluid microRNAs on Orthodontic Tooth Movement: a Split Mouth Study
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 27 (actual)
- Sponsor
- University of Catania · Academic / Other
- Sex
- All
- Age
- 11 Years – 18 Years
- Healthy volunteers
- Accepted
Summary
A split-mouth study is conducted in order to evaluate the impact of orthodontic movement on the expression of gingival crevicular fluid miRNAs related to inflammation and osteoclastogenesis during canine distalization following asymmetrical extraction treatment of upper first premolars. Samples of gingival crevicular fluid on the mesial and distal side of the canines to be examined will be performed during the baseline and during various follow-ups.
Detailed description
A split-mouth study is conducted in order to evaluate the impact of orthodontic movement on the expression of gingival crevicular fluid miRNAs related to inflammation and osteoclastogenesis during canine distalization following asymmetrical extraction treatment of upper first premolars. Orthodontic tooth movement induces bone remodeling by various signaling pathways. The variations in miRNAs expression and their impact in inflammation and osteoclastogenesis during the various stages of orthodontic tooth movements is not fully understood. 58 patients requiring asymmetrical upper first premolar extraction for orthodontic purposes have been enrolled for this split-mouth study: the canines to be distalized on the extractive site are considered as the test group, the controlateral canines (on the side without first premolar extraction) areconsidered as normal controls.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Elastomeric powerchain | Canine distalization by engaging the elastomeric power chains onto the canine brackets. |
Timeline
- Start date
- 2020-05-15
- Primary completion
- 2023-07-28
- Completion
- 2023-09-30
- First posted
- 2023-09-05
- Last updated
- 2023-12-04
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT06023433. Inclusion in this directory is not an endorsement.