NCT06022445

Prospective Validation of CARPET Prognostic Model for Septic Shock After Allo-HSCT

Prospective Validation of CARPET Prognostic Model for Patients With Septic Shock After Allogeneic Hematopoietic Stem Cell Transplantation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Peking University People's Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Validation of CARPET prognostic model for septic shock after allo-HSCT: a multicenter, prospective, and cohort study

Detailed description

A clinical prognostic model named CARPET model for septic shock after allo-HSCT has been developed and internally retrospectively validated. A multicenter, prospective cohort study is planned to validate this clinical prediction model again. The equation of the prediction model for 28-day mortality was as follows: Probability(28-day mortality)=(exp⁡(Y))/(1+exp⁡(Y)) where Y=2.343+1.328\* Time of septic shock- 0.085\* Albumin + 0.016 \* Bilirubin-0.003\*PaO2/FiO2 +0.127\*Lactate- 0.011 \* Glomerular filtration rate

Conditions

• Stem Cell Transplant Complications

Interventions

Type	Name	Description
OTHER	CARPET prognostic model	For patients diagnosed with septic shock, we obtained the information in CARPET prognostic model including time of septic shock, albumin, bilirubin, PaO2/FiO2, lactate, and GFR. We calculated the CARPET risk score and the 28-day mortality probability according to CARPET logistic regression model.

Timeline

• Start date: 2023-09-01
• Primary completion: 2024-10-01
• Completion: 2024-12-30
• First posted: 2023-09-01
• Last updated: 2023-09-01

Locations

1 site across 1 country: China