NCT06020612

Interobserver Variability Desmoplasia

Desmoplasia in Cutaneous Squamous Cell Carcinoma: Inter Observer Agreement Between Dermatopathologists.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 50 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

According to the most recent guideline of the National Comprehensive Cancer Network (NCCN), desmoplasia is considered to be a very high risk factor for recurrence, metastasis and death in cutaneous squamous cell carcinoma (cSCC). The presence of desmoplasia is assessed by dermatopathologists during histological examination of cSCCs. However, the inter-observer agreement is between dermatopathologists in the assessment of desmoplasia is unclear. Studies on inter-observer variability in the assessment of differentiation grade in cSCCs showed that there is only a weak to moderate agreement among dermatopathologists in the assessment of differentiation grade (2-4). This study aims to investigate the interobserver agreement of desmoplasia between dermatopathologists. In this prospective study, 50 cSCCs will be assessed for desmoplasia by at least eight dermatopathologists using a predefined definition.

Conditions

• Cutaneous Squamous Cell Carcinoma
• Pathology
• Recurrence
• Metastasis

Interventions

Type	Name	Description
OTHER	Assessment by dermatopathologists	Histological assessment of the cSCCs by eight dermatopathologists.

Timeline

• Start date: 2023-07-01
• Primary completion: 2024-05-01
• Completion: 2024-06-01
• First posted: 2023-08-31
• Last updated: 2025-04-04

Locations

1 site across 1 country: Netherlands