NCT06018090

Microembolic Detection in Acute Ischemic Stroke Patients With Atrial Fibrillation and Outcome

Microembolic Detection in Acute Ischemic Stroke Patients With Atrial Fibrillation and Outcome - A Prospective Multicenter Study With Transcranial Doppler

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 61 (actual)
• Sponsor: Centro Hospitalar De São João, E.P.E. · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This multicenter international prospective cohort study will include patients with AIS with a known or newly diagnosed anticoagulant-naïve AF. All centers will use the same transcranial Doppler machine for one-hour monitoring with bilateral 2-MHz probes within 24 hours of symptom onset. Recordings will be analyzed for MES by a blinded central reader. The primary aim is to determine the proportion of patients with MES and the association of MES with functional outcomes assessed by a modified Rankin scale (mRS) score at 90 days.

Conditions

• Infarction, Brain
• Embolism
• Atrial Fibrillation

Interventions

Type	Name	Description
OTHER	The presence and rate of MES measured by TCD monitoring	TCD monitoring within 24 hours from the last known well time. Bilateral M1 segments of middle cerebral artery were insonated at a single depth with 2-MHz transducers secured by a probe-holder.

Timeline

• Start date: 2019-06-06
• Primary completion: 2022-08-31
• Completion: 2022-10-06
• First posted: 2023-08-30
• Last updated: 2023-08-30

Locations

1 site across 1 country: Portugal