NCT06014606

Learning and Decision-making

How Does the Brain Learn About Positive and Negative Things?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Maastricht University · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

A fundamental aspect of daily life decision-making involves the evaluation of costs and benefits. Neural systems underlying cost-benefit evaluation have been extensively examined, but the specific role of different neurotransmitters remains unclear. Numerous studies suggest that both dopamine (DA) and norepinephrine (NE) are closely related to reinforcement learning, guided exploration/exploitation, and behavioural energisation, although no studies to date have investigated the distinct role of DA and NE on cost-benefit decision-making and learning in human subjects.

Conditions

• Motivation

Interventions

Type	Name	Description
DRUG	placebo	oral formulation
DRUG	haloperidol 2mg	oral formulation
DRUG	propranolol 40mg	oral formulation

Timeline

• Start date: 2021-03-01
• Primary completion: 2023-04-30
• Completion: 2023-08-16
• First posted: 2023-08-28
• Last updated: 2023-08-28

Locations

1 site across 1 country: Netherlands