NCT06007274

Troponin to Detect Major Cardiovasculaire Advserse Events on Immune Checkpoint Inhibitors

Troponin to Detect Major Cardiovasculaire Advserse Events on Immune: a Case Control Retrospective Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 300 (actual)
• Sponsor: Institut Mutualiste Montsouris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Recent guidelines suggest the use of troponin to detect immnune related cardiovascular advserse events in patients treated by immune checkpoint inhibitors for cancer. However, there is no proof that patients on immune checkpoint inhibitors benefit from this active surveillance strategy. The suspicion of cardiovascular events may lead to the interruption of cancer therapies. The TILT study aims at assessing: (i) the efficiency of troponin measurments in asymptomatic patients to prevent the further advent of major cardiovascular events; (ii) its safety in terms of cancer therapy completion.

Detailed description

Retrospective two-center study comparing two groups of patients on immune checkpoint inhibitors: * Group 1: active surveillance by serial troponin measures not prompted by cardiovascular symptoms ; * Group 2: no troponin measures. For any solid cancer or stage.

Conditions

• Cancer
• Immune Checkpoint Inhibitor
• Cardiovascular Biomarkers

Interventions

Type	Name	Description
OTHER	No intervention	No intervention

Timeline

• Start date: 2023-07-01
• Primary completion: 2024-04-01
• Completion: 2024-07-01
• First posted: 2023-08-23
• Last updated: 2026-04-08

Locations

1 site across 1 country: France