NCT06006832

A Prospective Cohort Study of Myasthenia Gravis in China

Clinical Characteristics, Prognosis and Biomarkers of Myasthenia Gravis: a Prospective Cohort Study in China

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 202 (estimated)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this prospective cohort study is to investigate long-term therapeutic strategies for myasthenia gravis (MG) and identify potential biomarkers. The main questions it aims to answer are: 1. Whether low-dose oral steroids may lead to a reduction in the recurrence rate among patients with MG. 2. To identify potential biomarkers that can predict disease progression and prognosis. This study recruits well-controlled patients with MG. Based on patient preferences and considerations such as coexisting conditions (e.g., uncontrolled hypertension, diabetes, severe osteoporosis, obesity), the participants will be non-randomly divided into two groups: a maintenance steroid therapy group and a withdrawal group (withdraw all immunosuppresants). Subsequently, these groups of patients will undergo long-term follow-up assessments.

Conditions

• Myasthenia Gravis

Interventions

Type	Name	Description
DRUG	Steroid Drug	Maintaining low-dose oral steroids
OTHER	Withdraw all immunosuppresants	Withdraw all immunosuppresants

Timeline

• Start date: 2023-08-20
• Primary completion: 2026-09-30
• Completion: 2026-09-30
• First posted: 2023-08-23
• Last updated: 2024-01-12

Locations

1 site across 1 country: China