NCT06004687

Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function

Effects of Acetaminophen Preemptive Analgesia on Anesthesia Recovery Time and Postoperative Cognitive Function in Patients Undergoing Gastrointestinal Tumor Surgery

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Affiliated Hospital of Nantong University · Academic / Other
• Sex: All
• Age: 16 Years – 88 Years
• Healthy volunteers: Not accepted

Summary

Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time. Pre-analgesia can reverse the effects of nociceptive stimulation on recovery from general anesthesia and postoperative cognitive function. Intravenous injection of non-steroidal drugs can effectively reduce postoperative pain and the use of opioids. Therefore, This study selected acetaminophen mannitol injection for preemptive analgesia to observe the effects on anesthesia recovery time and postoperative cognitive function of patients undergoing gastrointestinal tumor surgery, providing new ideas for reducing cognitive dysfunction in patients undergoing gastrointestinal tumor surgery

Detailed description

By administering acetaminophen to patients with gastrointestinal tumors before surgery, recording the time to recovery from anesthesia, and assessing cognitive function status by CAM on the first, third, and seventh day after surgery

Conditions

• Cognitive Function

Interventions

Type	Name	Description
DRUG	acetaminophen mannitol	Intravenous acetaminophen was administered 30 minutes before anesthesia
DRUG	Normal saline	Intravenous acetaminophen was administered 30 minutes before anesthesia

Timeline

• Start date: 2023-07-26
• Primary completion: 2024-05-30
• Completion: 2024-12-30
• First posted: 2023-08-22
• Last updated: 2023-08-22

Locations

1 site across 1 country: China