NCT06003660

Brain Neuronal Networks, Chemosensory and Trigeminal Functions in Allo-HSCT

BrainFlavor: Brain Neuronal Networks and Chemosensory and Trigeminal Functions in Allogeneic Hematopoietic Stem Cell Transplantation - a Prospective Cohort-study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 70 (estimated)
• Sponsor: University of Oslo · Academic / Other
• Sex: All
• Age: 30 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The goal of this prospective, cohort study is to learn about smell, taste and trigeminal dysfunction in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). The research team hypothesizes that treatment with allo-HSCT will induce: * Distortion of taste and smell and trigeminal functions like cooling, tingling, and burning sensations. * Reduced saliva production leading to oral dryness and dental caries. * Changes in the connectivity of the taste-, smell- and pain-cortical brain regions.

Detailed description

Participants will undergo various tests: * Smell function assessment with Sniffin' Sticks. * Taste function assessment with Taste Strips. * Oral trigeminal function assessment with von Frey filaments . * Salivary assessment with the Summated Xerostomia Inventory-Dutch questionnaire. * Salivary flow will be measured using salivary flow rate - stimulated whole saliva (SWS). * A clinical oral examination will be done to obtain a Clinical Oral Dryness Score. * Qualitative smell, taste and trigeminal dysfunction will be assessed using a questionnaire. * Radiological and clinical examinations will be performed to evaluate dental and oral mucosal status. * Quality of life using questionnaire. * Nutritional status using questionnaire. * Magnetic resonance imaging of the brain will be taken to capture regions-of-interest for the three different networks of interest; (i) the gustatory network reflecting changes in taste perception, (ii) the olfactory network, related to the changes in smell, and (iii) the pain matrix reflecting pain. There will be a comparisons between the patients and healthy controls.

Conditions

• Hematopoietic Stem Cell Transplantation

Timeline

• Start date: 2023-08-10
• Primary completion: 2025-12-30
• Completion: 2026-06-30
• First posted: 2023-08-22
• Last updated: 2025-03-26

Locations

1 site across 1 country: Norway