NCT06000306

MRD Monitoring by Digital Droplet PCR in the Early Period After Allo-HSCT to Predict Patients at High Risk of Relapse

Measurable Residual Disease Monitoring by Digital Droplet PCR in the Early Period After Allogeneic Hematopoietic Stem Cell Transplantation to Predict Patients at High Risk of Relapse

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 192 (actual)
• Sponsor: Zhejiang University · Academic / Other
• Sex: All
• Age: 12 Years – 70 Years
• Healthy volunteers: —

Summary

A study on the Effectiveness of digital droplet PCR in monitoring measurable residual disease during the early period after allogeneic hematopoietic stem cell transplantation to predict patients at high risk of relapse

Detailed description

This is a retrospective and multicenter clinical study.This study is indicated for patients with hematological malignancies who underwent allo-HSCT. It aims to evaluate the effectiveness of digital droplet PCR in monitoring measurable residual disease during the early period after allogeneic hematopoietic stem cell transplantation to predict patients at high risk of relapse. 192 patients will be enrolled. The clinical end points include cumulative incidence of relapse, relapse-free survival, non-relapse mortality, and overall survival.

Conditions

• Measurable Residual Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Digital Droplet PCR	Measurable residual disease Monitoring by Digital Droplet PCR in the Early Posttransplant Period

Timeline

• Start date: 2018-01-01
• Primary completion: 2021-08-31
• Completion: 2023-07-31
• First posted: 2023-08-21
• Last updated: 2023-08-22

Locations

1 site across 1 country: China