NCT05998772

Influence of Glucose on Metabolism and Clinical Symptoms of Patients With Parkinson's Disease

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: University Hospital Schleswig-Holstein · Academic / Other
• Sex: All
• Age: 50 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Many patients with Parkinson's Disease (PD) report an increased consumption of fast-acting sugars. This tendency to consume sweet, high-sugar foods occurs in some patients even before the onset of cardinal motor symptoms. Some recent studies have demonstrated that PD patients have an increased consumption of fast-acting carbohydrates compared to healthy controls. However, the reason for this change in eating behavior has not yet been adequately explained. It is discussed that the increased sugar intake leads to an increased dopamine release in the brain via an increase in insulin and thus to an improvement in clinical symptoms. This study investigates the influence of fast-acting carbohydrates on insulin and glucose blood levels as well as motor and non-motor symptoms in patients with PD using an oral glucose tolerance test and a placebo oral glucose tolerance test in a crossover design.

Conditions

• Parkinson Disease
• Nutritional and Metabolic Diseases
• Sugar Intake

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Oral Glucose Tolerance Test	Application of 82,5 g of glucose monohydrate solved in 300ml water
OTHER	Placebo Oral Glucose Tolerance Test	Application of 125mg sucralose solved in 300ml water

Timeline

• Start date: 2023-09-01
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2023-08-21
• Last updated: 2025-09-22

Locations

1 site across 1 country: Germany