NCT05995496

Changes in Inhibition and Valuation After Eating

Dynamic Neural Computations Underlying Cognitive Control in Bulimia Nervosa

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Icahn School of Medicine at Mount Sinai · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment. This project aims to understand how predictions and value-based decisions about control may be abnormally influenced by eating in individuals with BN, thereby maintaining cycles of binge eating, purging, and restriction.

Detailed description

The overarching goal of this project is to test a neurocomputational model of BN that incorporates learning and decision-making components of control. The study combines functional magnetic resonance imaging (fMRI), computational modeling, and real-time mobile assessments to examine the influences of acute fasting and eating on brain function and associated control-related updating and effort-valuation processes in BN. More specifically, the study has the following main objectives: 1) To determine the influence of eating on control-related prediction updating in BN.; 2) To determine the influence of eating on control-related cognitive effort valuation in BN; 3) To use state-specific neural activation to predict BN symptoms.

Conditions

• Bulimia Nervosa

Interventions

Type	Name	Description
OTHER	Fasting state	16 hours of fasting
OTHER	Fed state	Fed a standardized meal
OTHER	Magnetic Resonance Imaging	Neuroimaging with computational modeling

Timeline

• Start date: 2023-12-12
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2023-08-16
• Last updated: 2026-02-17

Locations

1 site across 1 country: United States