NCT05995067

The Potential Association of Long Non-coding RNA (NEAT1 and MALAT1) in the Process of Epithelial-mesenchymal Transition in Periodontitis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 48 (actual)
• Sponsor: Ali A Abdulkareem · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Periodontitis is a polymicrobial, inflammatory condition affecting tooth-supporting tissues. It is characterized by a progressive loss of epithelial attachment and resorption of alveolar bone, which can lead to tooth loss. Epithelial-mesenchymal transition (EMT) has been proposed as a reversible process that shifts the cell phenotype from epithelial to mesenchymal-like and may be involved in the process of periodontal inflammation either completely or partially. Long non-coding RNAs (lncRNAs) are a large class of regulatory transcripts longer than 200 nucleotides lacking evident protein-coding potential. Studies have shown that lncRNA dysregulation plays key roles in human diseases, including cancer, by modulating the epithelial-mesenchymal transition (EMT). The involvement of lncRNAs markers in the pathogenesis of periodontal disease induced EMT has not been studied thoroughly and have created a gap in the knowledge.

Conditions

• Periodontal Disease, AVDC Stage 3and 4
• Epithelial Mesenchymal Transition
• Long Noncoding RNA

Interventions

Type	Name	Description
OTHER	periodontitis challenge	control will be compared to diseased group suffering from periodontal disease.

Timeline

• Start date: 2022-02-14
• Primary completion: 2024-01-30
• Completion: 2024-01-30
• First posted: 2023-08-16
• Last updated: 2023-12-12

Locations

1 site across 1 country: Iraq