NCT05994287

Pain Treatment With Combinations of NSAIDs

Pain Treatment After Joint Surgery With a Combination of Aspirin, Ketorolac, and Celecoxib.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 105 (actual)
• Sponsor: Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The search for new safe and effective methods of pain relief after surgery on large joints is still an urgent problem. The most optimal approach in the treatment of postoperative pain is the use of multimodal analgesia with a different mechanism of action that act on various mechanisms of pain and can include opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, anticonvulsants, NMDA antagonists, alpha-2-agonists, and sodium and calcium channel blocking agents, as well as local anesthetics. NSAIDs are the most popular and safe means for pain relief. Therefore, a lot of efforts are aimed at increasing the effectiveness of NSAIDs use. The aim of this study was to evaluate the effectiveness of simultaneously administering two or three NSAIDs, compared to using only one NSAID, for pain relief after surgery on large joints such as hip or knee arthroplasty.

Detailed description

This is 6 days, randomized, double blind, parallel group, single-center study in 105 subjects. The distribution into groups was carried out by sequentially alternating the set into 4 groups celecoxib 400 mg orally daily, aspirin 100 mg and ketorolac 90 mg orally daily, ketorolac 90 mg and celecoxib 400 mg orally daily; aspirin 200 mg, ketorolac 90 mg and celecoxib 400 mg orally daily.

Conditions

• Postoperative Pain, Acute

Interventions

Type	Name	Description
DRUG	Aspirin	The patients received aspirin in a dose of 100 mg orally daily.
DRUG	Ketorolac	The patients received ketorolac in a dose of 90 mg mg orally daily.
DRUG	Celecoxib	The patients received celecoxib in a dose of 400 mg orally daily.

Timeline

• Start date: 2021-01-01
• Primary completion: 2022-01-01
• Completion: 2023-01-01
• First posted: 2023-08-16
• Last updated: 2024-01-25

Locations

1 site across 1 country: Russia