NCT05993182

Comparative Study Among Different Doses of Ephedrine During Elective Cesarean Section Under Subarachnoid Block.

Comparative Study Among Different Doses of Ephedrine During Elective Cesarean Section Under Subarachnoid Block - Time to Event Analysis.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 300 (actual)
• Sponsor: Aswan University · Academic / Other
• Sex: Female
• Age: 20 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

compare the time of second hypotension after administration of three different doses of ephedrine 5,10,15 mg

Detailed description

In cesarean section, under subarachnoid block the most common complication is hypotension with a reported incidence greater than 80%. Hypotension may occur even after left uterine displacement and preloading with crystalloid. The severity of hypotension depends on the degree of aortocaval compression syndrome, the amount of crystalloid preloading, doses of local anesthetic drugs administered. The most effective treatment of hypotension associated with cesarean section under subarachnoid block is the administration of vasopressor drugs.

Conditions

• Anesthesia
• Cesarean Section Complications
• Subarachnoid Block

Interventions

Type	Name	Description
DRUG	Ephedrine 5mg	Patients received 5mg bolus dose of ephedrine Intravenous after the first hypotension \[ Base line time or starting point is first hypotension\]
DRUG	Ephedrine 10mg	Patients received 10mg bolus dose of ephedrine Intravenous after the first hypotension \[ Base line time or starting point is first hypotension\]
DRUG	Ephedrine 15mg	Patients received 15mg bolus dose of ephedrine Intravenous after the first hypotension \[ Base line time or starting point is first hypotension\]

Timeline

• Start date: 2023-08-20
• Primary completion: 2024-01-01
• Completion: 2024-01-01
• First posted: 2023-08-15
• Last updated: 2024-03-01

Locations

1 site across 1 country: Egypt